From the distribution of 3,300 Narcan kits to first responder agencies throughout Arkansas, 91 lives have been saved since Jan. 1, 2018. Among the items contained in a Narcan kit are two Naloxone nasal sprays, an opioid antagonist used to reverse the effects of an opioid induced overdose.

“Our goal is to get the life-saving naloxone kits in the hands of all first responders in the state, which includes them completing a training program,” Arkansas Drug Director Kirk Lane said. “In the near future, we also want to distribute naloxone kits to various people in society. When a life is saved with naloxone, there is hope for recovery.”

The 1,300 Narcan kits were provided by the Criminal Justice Institute through a grant provided by the Blue & You Foundation for a Healthier Arkansas.

Though it should be used in an emergency situation (a suspected opioid overdose), Naloxone has no effect on non-opioid overdoses. Naloxone is available for purchase at some pharmacies in Arkansas.

To reduce the morbidity and mortality of opioid overdoses in Arkansas, Arkansas Governor Asa Hutchinson has a standing order [Arkansas Code § 17-92- 101(16)] allowing Arkansas-licensed pharmacists to initiate naloxone therapy including ordering, dispensing and/or administering naloxone, along with any necessary supplies for administration, to eligible persons who are at risk of experiencing an opioid-related overdose, or who are family members, friends, or others who are in a position to assist a person at risk of experiencing an opioid-related overdose.

Arkansas is 1 of 40 states exercising the Good Samaritan Overdose Immunity Laws, which encourages people to seek out medical attention for an overdose or for follow-up care after naloxone has been administered. These laws generally provide immunity from arrest, charge or prosecution for certain controlled substance possession and paraphernalia offenses when a person who is either experiencing an opiate-related overdose or observing one calls 911 for assistance or seeks medical attention. For more information: http://www.ncsl.org/research/civil-and-criminal-justice/drug-overdose-immunity-good-samaritan-laws.aspx.

This “How to talk to your doctor handbook” is provided by the University of Arkansas Division of Agriculture, Research & Extension, and the University of Arkansas for Medical Sciences’ Center for Health Literacy. Download a copy here:

Nearly 146 tons of prescription medications have been collected in the state since the first Arkansas Prescription Drug Take Back Day in 2010! Starting off 2018 with a bang, Arkansans donated more than 28 thousand pounds of medications on April 28!

Justin King, Assistant Special Agent in Charge of the DEA-Little Rock District Office, said that, “Altogether, the 15 Prescription drug take back events have produced the return of almost 146 tons of unneeded medications, estimated at 406.2 million pills. Due to the commitment, dedication, and effort of the Arkansas Law Enforcement Community, its partners, and the multi-agency coalition, and due to excellent participation by Arkansans in all areas of the state, the take back events have been successful above and beyond all expectations.”

BACKGROUND:

The Office of National Drug Control Policy (ONDCP), as part of its National Drug Control Strategy, called for an increase of prescription drug return and disposal programs as a means to curbing prescription drug abuse. In early 2010, a coalition led by the State Drug Director, the Attorney General, both Arkansas Districts of the U.S. Attorney’s Office, and numerous federal, local, and state agencies, prevention professionals, and private organizations, launched an ongoing education program to encourage everyone to “Monitor, Secure, and Dispose” their prescription medications.

As part of the “Monitor, Secure, and Dispose” effort, the coalition organized Arkansas’s participation in the U.S. Drug Enforcement Administration’s National Prescription Take-Back Initiative, and take back events took place on September 25, 2010, April 30, 2011, October 29, 2011, April 28, 2012, September 29, 2012, April 27, 2013, October 26, 2013, April 26, 2014, and September 27, 2014. DEA announced the discontinuation of the national initiative in September 2014, but an Arkansas take back event under the leadership of partners within the state was held on April 25, 2015. DEA then reinstated the program nationally, and events since have been held on September 26, 2015, April 30, 2016, October 22, 2016, April 29, 2017, October 28, 2017, and April 28,2018. DISCLAIMER: **Collectively, there have been 16 total Arkansas prescription drug take back events: one local and 15 national events. Results from the State Take Back in Spring 2015 were rolled into the total results for National Take Back 10 held September 26, 2015.

STATISTICAL INFORMATION:

Including all 15 events:

* Arkansas ranks #3 nationally in pounds collected per capita with 0.097 pounds per person, just barely behind Wisconsin with 0.101 pounds per person and Maine with 0.244 pounds per person. (Determined using 2017 census estimates)

* Despite being just thirty-third in population among all states, Arkansas ranks #13 in total weight collected.

* Arkansas averaged 62 more law enforcement agencies per event than the national average.

* Also, per event, Arkansas averaged 182 collection sites – the national average per state was 116 per event.

* The four-state DEA region consisting of Alabama, Arkansas, Louisiana, and Mississippi pooled a total weight of 442,050 pounds for all 15 Take Backs. Arkansas, despite being the least populated of the four:

1. Accounts for 66% of the total weight, collecting 141,298 pounds more than the other three states combined;

2. Averages more participating law enforcement agencies than the other three states combined; and,

3. Accounts for 52% of the region’s total sites for Take Back 15.

For Take Back 15, only:

* Arkansas ranks #13 nationally in weight collected.

* Per capita, Arkansas continues to rank 5th in weight collected. Maine ranks #1, followed by New Hampshire,Wisconsin and Vermont, respectively.

* Arkansas ranks 10th in the number of registered collection sites and 9th in the number of participating law enforcement agencies.

* Per capita, Arkansas ranks 4th in registered collection sites and 3rd in participating law enforcement agencies.

***Official totals will not be available for a few days*****

WASHINGTON – Americans nationwide did their part to drop off a record number of unused, unwanted or expired prescription medications during the DEA’s 15th National Prescription Drug Take Back Day, at close to 6,000 sites across the country. Together with a record-setting amount of local, state and federal partners, DEA collected and destroyed close to one million pounds—nearly 475 tons—of potentially dangerous expired, unused, and unwanted prescription drugs, making it the most successful event in DEA history.

This brings the total amount of prescription drugs collected by DEA since the fall of 2010 to 9,964,714 pounds, or 4,982 tons.

“Today we are facing the worst drug crisis in American history, with one American dying of a drug overdose every nine minutes,” said Attorney General Jeff Sessions. “An unprecedented crisis like this one demands an unprecedented response–and that’s why President Trump has made this issue a priority for this administration. DEA’s National Drug Take Back Days are important opportunities for people to turn in unwanted and potentially addictive drugs with no questions asked. These Take Back Days continue to break records, with the latest taking nearly 1 million pounds of prescription drugs off of our streets. And so I want to thank DEA and especially every American who participated in this event. I have no doubt it will help keep drugs out of the wrong hands and stop the spread of addiction.”

“National Prescription Drug Take Back Day is a day for every American, in every community across the country, to come together and do his or her part to fight the opioid crisis – simply by disposing of unwanted prescription medications from their medicine cabinets,” said DEA Acting Administrator Robert W. Patterson. “This event – our 15th – brings us together with local, state and federal partners to fight the abuse of prescription drugs that is fueling the nation’s opioid epidemic.”

Now in its 9th year, National Prescription Drug Take Back Day events continue to remove ever-higher amounts of opioids and other medicines from the nation’s homes, where they could be stolen and abused by family members and visitors, including children and teens.

This initiative addresses a vital public safety and public health issue. Medicines that languish in home cabinets are highly susceptible to diversion, misuse and abuse. Rates of prescription drug abuse in the U.S. are alarmingly high, as are the number of accidental poisonings and overdoses due to these drugs. Studies show that a majority of abused prescription drugs are obtained from family and friends, including from the home medicine cabinet.

DEA launched its prescription drug take back program when both the Environmental Protection Agency and the Food and Drug Administration advised the public that their usual methods for disposing of unused medicines—flushing them down the toilet or throwing them in the trash—posed potential safety and health hazards.

Helping people to dispose of potentially harmful prescription drugs is just one way DEA is working to reduce the addiction and overdose deaths plaguing this country due to opioid medications.

Complete results for DEA’s fall Take Back Day are available at www.deatakeback.com. DEA’s next Prescription Drug Take Back Day is October 27, 2018.

In the ongoing fight against the abuse of opioids, the University of Arkansas for Medical Sciences has launched a free weekly education and consultation service for Arkansas health-care providers, Governor Asa Hutchinson announced at a press conference today.

The AR-IMPACT (Arkansas Improving Multidisciplinary Pain Care Treatment) partnership includes the UAMS, the Office of the State Drug Director, the Arkansas Department of Health, the Arkansas Departm

ent of Human Services, the Arkansas State Medical Board, Blue Cross-Blue Shield, the Arkansas Medical Society and the Arkansas Academy of Family Physicians.

“This education portal for doctors is an important new weapon in the fight against this terrible epidemic that is killing hundreds of Arkansans every year,” Governor Hutchinson said. “It is not an exaggeration to call this epidemic one of our state’s greatest challenges. Today we understand more about opioid drugs than we did a decade ago. With that advanced knowledge, we must utilize every tool possible to pass along this information to doctors so that we can save lives and spare more patients the tragedy of addiction.”

AR-IMPACT will provide weekly seminars at noon on Wednesdays that feature specialists in the treatment of pain and addiction, a physical therapist, a psychologist, and pharmacists who are trained in opioid-related issues. After the presentation, doctors may join via teleconference to discuss cases for individualized feedback about approaches to treatment.

The 16 professionals in the opioid-epidemic crisis who joined the governor at the press conference at the state capitol included UAMS Interim Chancellor Stephanie Gardner, who accepted a $104,000 check from Blue-Cross-Blue Shield.

“We are thankful to Arkansas Blue Cross and Blue Shield for their partnership as we work to improve pain management in Arkansas through UAMS AR-IMPACT,” Chancellor Gardner said. “As the state’s only health sciences university, UAMS is uniquely positioned to address this issue head on for the betterment of all Arkansans.”

Curtis Barnett, president and CEO of Arkansas Blue Cross, presented the check.

“Arkansas Blue Cross recognizes that the opioid epidemic threatens the health of the people of Arkansas in many ways,” President Barnett said. “For those in chronic pain and for those treating them, there is no easy solution. We already have been working with health-care providers to help get a better understanding of opioid prescribing patterns in Arkansas. We believe the new AR-IMPACT education program with UAMS will help doctors learn about resources and alternatives to managing pain. It will take everyone working together to truly impact this crisis.”

Kirk Lane, Director of the State Drug Office, said the epidemic is a priority.

“As drug director, I’ve talked with so many families who have been impacted, and it is clear that this crisis respects no class, race or income boundaries,” Director Lane said. “It is evident that a collaborative approach is necessary to change the direction of this epidemic. We will make that difference with education and the willingness to change.”

Those who wish to utilize the AR-IMPACT portal must register at www.arimpact.uams.edu.

“I feel that if an officer has Narcan, then they should only use it on children, officers and other significant situations that are not your average overdose,” Lonoke Co. Dispatcher.

Arkansas Democrat-Gazette(15 Apr 2018 by Amanda Claire Curcio) 

Makers of narcotic painkillers gave millions of dollars to Arkansas doctors between 2013 and 2016. At least 800 state residents died from opioid overdoses during the same period. Federal data reveal that opioid manufacturers directed $5 million in “general payments” to about three-quarters of the state’s doctors for consulting, meals, travel and promotional speaking.

A smaller group — 1,600 physicians — received a total of nearly $689,000 specifically to promote opioid products during the four-year period, an analysis of federal data by the Arkansas Democrat-Gazette shows. Taking money from drug companies doesn’t mean a doctor has done anything wrong, yet recent studies assert that these types of payments, even when under $50, affect how physicians prescribe. Some doctors, health experts and officials interviewed by the newspaper said that accepting money from pharmaceutical companies presents a conflict of interest for physicians.

“So many doctors are more merchants than they are physicians now,” said Dr. Janet Cathey, an assistant professor at the University of Arkansas for Medical Sciences. “How do doctors get away with it? Your ethical, legitimate doctors won’t do this.”

She described some doctors as complicit in the deluge of powerful prescription narcotics in the state, where there were 79 opioid pills for every one of Arkansas’ nearly 3 million residents in 2016, according to county-level health records. Cathey acknowledged that most of the state’s nearly 6,100 doctors accept payments from drug companies to promote various medications, not just opioids, but she says that taking money from opioid-makers is especially problematic considering how many Arkansans are affected by the opioid epidemic.

Last year, New Jersey and California capped promotional payments to doctors; Maine banned such contributions. Other health professionals say doctors aren’t so easily influenced.

“Doctors are well aware of the intentions behind the pharmaceutical industry. There is a difference between doctors getting bribes and doctors who believe in a product,” said Dr. Marvin Covey, a recently retired pain management specialist and former medical director of Pain Treatment Centers of America, which has eight offices in Arkansas.

“It is a slippery slope, however,” Covey added. “Doctors need to be very careful.”

Some policymakers say doctors shouldn’t bear all the blame for the opioid epidemic that has surged across the United States for at least a decade. Drug companies took advantage of a change in the guidelines the medical community uses to treat patients with chronic pain, said Dr. Joseph Thompson, president of the Arkansas Center for Health Improvement.

“But I can’t say that’s the only cause of the epidemic,” he said.

Doctors lacked clear guidance on how to best prescribe opioids, and there was a lack of education about the associated risks, the health policy center leader said.

“With the development of increasingly strong drugs, the potential for dependency and addiction went up,” he added.

Taking opioids activates certain brain receptors, and after repeated exposure to the drug, pain patients need opioids just to feel normal, Thompson explained. Pharmacists and drug distributors also bear some responsibility for fueling the state’s opioid epidemic, a recently filed lawsuit against the opioid industry alleges.

INFLUENCING DOCTORS

Doctors who took the most money from opioid-makers practiced medicine in counties with the highest opioid prescribing rates.

For instance, Sebastian, Craighead and Independence counties’ physicians received more payments from opioid-makers, when adjusted for population, than all counties but one, according to the newspaper’s analysis of 2016 federal data.

The number of opioid prescriptions in those counties ranged from 157 to 169 for every 100 residents, data from the federal Centers for Disease and Prevention Control show. The state average prescription rate in 2016 was 115 per 100 residents; the U.S. rate that year was 66 per 100.

Information about what drug companies pay doctors comes from the newspaper’s analysis of Open Payments, a data resource compiled by the CDC.

Doctors don’t get money only for promoting opioids, the payments database shows. The same firms that make pain pills also produce non-narcotic medications and pay doctors for promotional activities related to those drugs.

Opioid-makers also paid more than $58 million to physicians to conduct research between 2013 and 2016. Only $8,000 in research payments went to opioid-specific projects.

Studies and national news reporting reveal that incentives to doctors from drug companies affect how they prescribe.

Analysis by Harvard University researchers and cable news channel CNN, released last month, found that doctors who write the most opioid prescriptions often receive the most general payments from opioid manufacturers.

Doctors whose opioid prescription volume ranked among the top 5 percent received twice as much money from opioid manufacturers as compared with doctors whose prescription volume fell in the middle, the researchers found. Doctors in the top 1 percent usually received four times as much as a typical doctor.

The Harvard researchers looked at records of almost 400,000 doctors who wrote opioid prescriptions to Medicare patients between 2014 and 2015. Of those physicians, 54 percent received payments from opioid-makers, they found. The study analyzed both the Open Payments database and another federal database that tracks Medicare prescriptions that doctors write.

A 2017 University of North Carolina at Chapel Hill report also found that doctors were between 29 percent and 78 percent more likely to prescribe a drug promoted by a pharmaceutical company. A 2015 study, published last year in the Journal of the American Medical Association, yielded similar results when looking at different medications.

PAIN PRACTICES

The emergence of OxyContin, Purdue Pharma’s brand-name oxycodone, and a subsequent flood of other narcotic pain pills prompted an “explosion” in the pain management profession, according to UAMS professor Cathey.

“It became just so lucrative to be a pain doctor,” she said.

To Cathey, the issue of over-prescribing became apparent when a car crash left her paralyzed and doctors told her to take an excessive amount of medication to treat the resulting chronic nerve pain.

“We’ve become such a pill-oriented society,” she said. “So of course patients think it’s normal to take all these drugs.”

Within a few years of OxyContin’s 1996 debut, drug companies’ direct marketing to doctors jumped tremendously.

The number of times drug company representatives met with doctors rose from an average of four or five times a month through the 1990s to up to 16 visits a month by early 2004, according to a study in the Journal of the American Medical Association and a survey in the New England Journal of Medicine.

Almost 100,000 drug industry representatives tried to influence almost 700,000 physicians at that time, federal Health Resources and Services Administration data show.

Collaboration between an influential hospital accreditor and the opioid industry in 2001 changed how doctors treated pain, further contributing to the rising epidemic, Cathey said.

The Joint Commission, a nonprofit certifying 99 percent of all U.S. health care organizations, including in Arkansas, released new guidelines that counted pain as the fifth vital sign, alongside pulse rate, body temperature, respiration rate and blood pressure.

These “Pain Management Standards” encouraged increased treatment of pain, including heavier use of medication. Essentially, under the standards, a compassionate doctor must try to alleviate the patient’s pain; the simplest way to do so was to prescribe a pain pill.

That same year, the Joint Commission collaborated with the National Pharmaceutical Council, made up of several opioid manufacturers and distributors, to publish a report saying that pain was undertreated and that there were “adverse consequences of inadequately managed pain.”

The basis for the commission’s standards is often attributed to a 1996 article in the New England Journal of Medicine, titled “Assessment of Patients’ Pain.” The article cites a study that says doctors and nurses too often discounted patients’ perceptions of their own pain. The majority of patients surveyed for the study had cancer or chronic diseases like sickle cell anemia or AIDS.

Another 2001 Joint Commission report said that doctors had “inaccurate and exaggerated concerns about addiction, tolerance and risk of death.”

Dr. David Baker, the commission’s executive vice president, says the 2001 standards should not be blamed for the opioid epidemic. At the time, doctors failed to address pain, which was a “national and international public health problem,” Baker said.

“We needed to have other ways for organizations to improve pain control,” he said. “That was an important shift away from the individual physicians and really to the organizations and systems of care.”

PROMOTING PILLS

Two lawsuits filed in separate Arkansas courts last month say the shift in how the medical profession viewed pain and its treatment helped push more pain pills into the hands of patients.

The suits also accuse the drug companies of taking advantage of primary care physicians who might not be well-trained in managing pain.

Both suits allege that certain drug companies unleashed the opioid crisis in Arkansas in part by compensating doctors to promote the use of addictive opioids to colleagues.

The paid doctors were part of the drug makers’ “speaker bureaus” that promoted particular drugs during forums attended by other doctors, according to the suits.

“These speakers give the false impression that they are providing unbiased and medically accurate presentations when they are, in fact, presenting a script prepared by manufacturer(s),” both suits say.

The speaker programs were one part of a marketing scheme designed to convince doctors and patients that opioids can cure chronic pain, without revealing the probability of addiction and related long-term side effects, the suits claim.

Arkansas Attorney General Leslie Rutledge filed the state’s suit in Pulaski County Circuit Court on March 29. The complaint targets three companies — Purdue Pharma, Endo Pharmaceuticals and Johnson & Johnson — which she said manufacture the most-used opioids in Arkansas.

A coalition of 87 Arkansas counties and cities filed a lawsuit in Crittenden County Circuit Court on March 19 against 52 opioid manufacturers, including Purdue, Endo Pharmaceuticals and Johnson & Johnson. That effort is led by the Association of Arkansas Counties and the Arkansas Municipal League.

Both pharmacists and the opioid distributors who let those pharmacists order large quantities of opioids unchecked also contributed to the health problem, the coalition-led suit asserts.

The suit named pharmacist Christopher Watson, who was sentenced to 10 years in federal prison for conspiracy to unlawfully distribute pain pills last year. FBI agents found that Watson sold tens of thousands of hydrocodone and oxycodone pills after-hours from Perry County Food and Drug, a retail pharmacy owned by Watson’s father.

The two lawsuits seek punitive monetary damages. The state’s suit also seeks an injunction to stop what it calls deceptive marketing practices.

Opioid-makers named in the suits haven’t responded to the newspaper’s repeated requests for interviews.

Arkansas doctors receive fewer contributions from drug companies now than they did in the past, said Thompson, the Arkansas Health Improvement Center executive.

Physicians are barred from having certain types of meetings with drug representatives and must disclose conflicts of interest, he said.

Thompson said legislators and regulators “need to intentionally and explicitly create policies” requiring doctors to disclose to the Arkansas State Medical Board when they receive significant contributions from drug companies.

“There have been steps to restrict the pharmaceutical and medical device companies to influence a doctor’s prescribing patterns,” he said. “It’s a lot better than it used to be.”

The Open Payments database, which shows contributions drug companies made to individual doctors, was required by the 2010 Physician Payments Sunshine Act, enacted the same year as the Patient Protection and Affordable Care Act. Public records of such payments before 2013 aren’t available.

Doctors aren’t required to tell patients what payments they receive from drug companies.

The highest-paid Arkansas doctor in the federal database, Dr. Mahmood Ahmad, received more than $156,000 from opioid-makers between 2013 and 2015.

For years, the Arkansas State Medical Board investigated Ahmad for over-prescribing controlled substances, and in 2016, board members voted to revoke his license. That revocation has since been upheld by the Arkansas Court of Appeals.

During the disciplinary hearing, board attorney Kevin O’Dwyer called out Ahmad’s “routine reliance” on starting patients with high doses of opioids, improper patient record-keeping, gross negligence and “professional incompetence.”

O’Dwyer also cited allegations against the doctor in Alaska, where he had already surrendered his license to practice after regulators found that he had prescribed life-threatening amounts of controlled substances to patients in Anchorage.

Last year, one of Ahmad’s former patients, Cheryl Hartsfield, sued Ahmad and others in Pulaski County Circuit Court. The case is pending.

The suit says that Arizona-based Insys Therapeutics Inc. targeted Ahmad to bump up sales of Subsys, a spray made of fentanyl, an opioid 50 to 100 times stronger than morphine.

Corporate emails show that Insys was aware of Ahmad’s excessive prescribing, yet the company still paid the Sherwood doctor “speaker fees” in return for prescribing the drug, the suit claims.

Between 2014 and 2015, Ahmad wrote more than 1,450 Subsys prescriptions and collected nearly $150,000 from Insys, the suit states. By comparison, Ahmad had written roughly 50 prescriptions for the opioid spray before establishing a relationship with Insys.

In response, Insys denied that its actions were “deceptive, misleading, false or otherwise unconscionable,” according to court documents.

Ahmad now lives in Islamabad, court records indicate.

Medical board records don’t show any reported licensing problems for other top-paid Arkansas doctors in the Open Payments database.

UAMS bioethics professor Micah Hester says it’s important for doctors to be involved with the development of medicines their patients will eventually use, which means doctors must interact with the pharmaceutical industry.

Conflicts of interest that arise when doctors take money from drug companies can be mitigated, he said.

Physicians should tell patients about their affiliations with drug manufacturers before prescribing, and offer patients alternative treatments, said Hester, who chairs the medical school’s Department of Medical Humanities and Bioethics.

Doctors also need to understand how receiving contributions can affect their behavior — even subconsciously, he said.

“We want intelligent decision-making by doctors, not unconscious bias doing our work,” he said. “We want to say we’re doing our best by our own determination. We want to be able to control outcomes, not just have them occur.”

LITTLE ROCK — The University of Arkansas for Medical Sciences (UAMS) is attacking the nationwide opioid epidemic on multiple fronts that have produced new research and treatment options for patients and health care providers across Arkansas and beyond.

“As the state’s only health sciences university, UAMS is uniquely positioned to address this issue head on for the betterment of all Arkansans,” said Interim Chancellor Stephanie Gardner, Pharm.D., Ed.D. “Our researchers are grounded in a scientific approach, our faculty are committed to both education and clinical care, and our influence in health care reaches throughout the state. We are summoning these resources in an effort to turn the tide on this deadly epidemic.”

There were 116 deaths per day from opioid-related drug overdoses in the United States in 2016, according to the U.S Department of Health and Human Services. Arkansas ranks second in the nation for its opioid prescribing rate with an average of 114.6 prescriptions per 100 people, according to U.S. Centers for Disease Control and Prevention data from 2014-2016.

Research to improve understanding of opioid addiction and its treatment is ongoing in departments across campus, and some of it is having national impact.

For example, the Centers for Disease Control Prevention Morbidity and Mortality Weekly Report published a study in 2017 led by UAMS pharmacy professor Bradley Martin, Pharm.D., Ph.D., that showed that by prescribing patients opioid supplies of three days or less, providers can reduce the likelihood of the patient using opioids chronically one to three years later.

The UAMS Psychiatric Research Institute’s Division of Health Services Research, directed by Teresa Hudson, Pharm.D., Ph.D., is conducting a variety of studies related to opioid addiction, including opioid addiction among people with mental health diagnoses and among veterans.

One study found that people with mental health and substance abuse diagnoses receiving therapy and regular doctor checkups were less likely to die, but only if they were not prescribed opioids or benzodiazepines. Another study showed that veterans from Iraq and Afghanistan were prescribed opioids at rates similar to the rest of the U.S. population, indicating that overprescribing is a nationwide issue not specific to veterans. Three related studies are looking at methods to decrease opioid use and improve pain management among veterans with chronic pain.

Peter Crooks, Ph.D., is working to develop safer opioid molecules that work better for pain than existing drugs, with fewer side effects and less potential for addiction. Within the Women’s Mental Health Program, Jessica L. Coker, M.D., is studying opioid addiction in pregnant women. Lisa Brents, Ph.D., is developing new therapies for opioid addiction during pregnancy that reduce fetal exposure to opioids. William Fantegrossi, Ph.D., is studying new types of opioids and whether they are more addictive than older types or require more aggressive treatments for dependence and overdose. Benjamin Teeter, Ph.D., is studying ways to more effectively distribute naloxone, which is used to treat opioid overdoses in emergency situations, in the community. Bradley Martin is also about to initiate a study to see if physical therapy can interrupt long-term opioid use among patients with low back pain.

The Psychiatric Research Institute’s Center for Addiction Research has many ongoing studies related to improving opioid detoxification treatments by testing different methods and drugs or combinations of the two.

In addition to performing the kind of research that could change physician behavior nationwide, UAMS clinicians are turning a critical eye to their own behavior in the name of improvement.

UAMS is the state’s largest public employer, with a hospital, five colleges, seven institutes, a Northwest Arkansas campus, a network of regional centers statewide and physician placement partnerships with Arkansas Children’s Hospital, the VA Medical Center and Baptist Health.

With such a wide reach, changes to the institution’s internal processes can have a huge impact.

For example, colorectal surgeons in the UAMS College of Medicine Department of Surgery set out to change the way its physicians helped their patients manage pain, limiting opioid use as part of a comprehensive Enhanced Recovery Protocol. The process began with a year of internal education about the new approach and the evidence to back it up, followed by an official kickoff in 2015.

The latest data show that over a two-year period, narcotic use decreased 40 percent. Patients who are not prescribed narcotics are well enough for discharge an average of 1.5 days sooner. Complications resulting in readmission are also down among those patients.

“When we looked at the data, we saved about $2 million over two years just in length of stay alone, and if we accounted for other factors, like the reduction in complications and readmissions, we’re probably saving more,” said Jonathan A. Laryea, M.D., colorectal surgeon and associate professor of surgery. “More importantly, what’s behind those numbers is that our patients are doing better and getting better sooner. We’ve known for some time in the literature that narcotics impede recovery and increase complications, but now we have our own institutional data to show that’s true.”

Meanwhile, the Department of Orthopaedic Surgery conducted a similar internal review and developed its own opioid prescription guidelines. Simon Mears, M.D., orthopaedic surgeon and professor of orthopaedic surgery, helped lead that effort. In a little more than a year, their narcotic prescriptions have decreased by a third.

Both Laryea and Mears said it’s common for patients to come to them for surgery already on high doses of opioids prescribed to them by other doctors.

“So we are working on it from both ends,” Mears said. “In orthopaedics, it’s been incredibly common in the past for people to be prescribed narcotics for things like osteoarthritis, when in fact they don’t help. There has also been evidence to show that if people are on narcotics before surgery, they actually do worse with something like a knee replacement. So communicating with patients about that has become a big part of our effort.”

With that issue in mind, the orthopaedics team enlisted the help of UAMS’ Center for Health Literacy, which produced clear and easy-to-read materials about opioids to help with doctor-patient discussions about pain management and expectations before and after surgery.